|
KMID : 1161420160190010038
|
|
Journal of Medicinal Food
2016 Volume.19 No. 1 p.38 ~ p.46
|
|
|
Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats
|
|
Zheng Hong-Mei
Choi Myung-Joo
Kim Jae-Min
Cha Kyung-Hoi
Lee Kye-Wan
Park Yu-Hwa
Hong Soon-Sun
Lee Don-Haeng
|
|
|
Abstract
|
|
|
|
The present study evaluated the protective effect of Centella asiatica (gotu kola) leaf extract (CAE) against indomethacin (IND)-induced gastric mucosal injury in rats. Gastric mucosal injury was induced by the oral administration of IND to the rats after a 24 h fast. CAE (50 or 250?mg/kg) or lansoprazole (a reference drug) was orally administrated 30?min before the IND administration, and 5?h later, the stomachs were removed to quantify the lesions. Orally administered CAE significantly reduced IND-induced gastric injury. The histopathological observations (hematoxylin?eosin and Periodic acid?Schiff staining) confirmed the protection against gastric mucosal injury. Also, CAE decreased the malondialdehyde content compared to the control group. Moreover, pretreatment with CAE resulted in a significant reduction in the elevated expression of tumor necrosis factor, Cyclooxygenase (COX)-2, and inducible nitric oxide synthase. These results suggested that CAE possesses gastroprotective effects against IND-induced gastric mucosal injury, which could be attributed to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion in the rat gastric mucosa.
|
|
|
KEYWORD
|
|
|
Centella asiatica leaf extractgastroprotectionindomethacinlipid peroxidation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|